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Lipospondin

 
 
單價 10.00 / g對比
銷量 暫無
發(fā)貨 四川成都市付款后3天內(nèi)
庫存 10000g起訂1g
品牌 成都云希
外觀 白色粉末
功效 皮膚護理
分子式 C21H35N5O4
過期 長期有效
更新 2021-07-05 16:42
 
詳細說明

1.Basic information:

Name: Lipospondin

Cas No:

Formula: C21H35N5O4

Molecular:685

Sequence: N-Elaidoyl-KFK

Purity: ≧95%

Grade: cosmetic

Source: synthetic

Stability: stable

Appearance: white powder

MSDS and COA: available for your reference

Delivery: promptly from stock

Appearance: white powder

 

2.Usage: prevent age-associated dermal alterations

 

3.DescriptionN-Elaidoyl-KFK as well as KFK were shown to activate LAP-TGF-beta both in vitro, using a solid phase assay with immobilized LAP-TGF-beta, and ex vivo using human dermal fibroblasts cultures. In both assays, as much as up to 10% of LAP-TGF-beta added could be recovered as active form. KQK, KQFK as well as their lipopeptide counterparts were inactive. Elaidyl-KFK-mediated LAP-TGF-beta activation led to up-regulation of collagen and TIMP-1 production and down regulation of PMA-induced MMP-1 expression in fibroblasts cultures. Those effects could be suppressed by supplementing cell culture medium with blocking TGF-beta antibody. Elaidyl-KFK inhibited MMP-2, MMP-9, MMP-3, MMP-1, in vitro with IC(50) equal to 1.2, 1.0, 0.24 and 8.9 microM, respectively. Its ex vivo inhibitory capacity, as assessed using skin tissue sections, towards the elastin-degrading capacity of MMP-9 was even more pronounced. At a 1 microM concentration, the lipopeptide decreased by up to 80% enzyme activity. Thus, "Lipospondin," i.e. elaidyl-KFK might be considered as a promising model *pound to prevent age-associated dermal alterations.

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